Retinoic ointment is a miracle cure. Fact or fiction?

• Is retinoic ointment effective for wrinkles?
• retinoic ointment for wrinkles - reviews from doctors and patients.

Retinoic ointment belongs to the group of topical retinoids. Its main active ingredient is Isotretinoin (13-cis-retinoic acid), which is, in principle, one of the most effective forms of vitamin A for reducing the depth of wrinkles.

Thus, the effectiveness of Isotretinoin significantly exceeds the effects of using most other forms of vitamin A. Everyone has heard about cosmetics with retinol, retinaldehyde, as well as retinol acetate - all of these are forms of vitamin A that are different in effectiveness. Compared with isotretinoin, a stronger anti-aging effect on The skin is treated only with a retinoid such as Tretinoin (retinoic acid).

Composition and release form

Retinoic ointment is a greasy, light-yellow product of uniform consistency, which contains Isotretinoin. It is this substance that determines the high biological activity of the drug. Isotretinoin belongs to the group of Retinoids and is a type of retinoic acid along with Tretinoin, which is more toxic and for this reason is rarely used.

Retinoids are substances close in structure and physiological action to Vitamin A - Retinol, and are chemically similar to it.

For clarity, the relationship between the chemical structure of vitamin A and its derivatives is shown below.

Isotretinoin is shown on the left and is completely cis-retinoic acid, that is, its chemical configuration in which the functional group is in the same plane as the double bond. Cis isomers are more reactive, i.e. have greater biological activity. In addition, it is safer than trans-retinoic acid - Tretinoin .

To date, among the six drugs registered in Russia, Isotretinoin Retinoic ointment is the only dosage form in the form of an ointment.

Therefore, if you come across a drug in the pharmacy in the form of an ointment or cream with a different name, where this active substance is indicated, then keep in mind that this is a counterfeit or fake.

The patent and rights to produce this ointment belong to the pharmaceutical industry.

Retinoic ointment is available in two concentrations:

0.5% - containing 0.05 g of Isotretinoin per 10 g of ointment and 1% containing 0.1 g, respectively.

The ointment also contains auxiliary components:

• Dibunol (antioxidant, antioxidant);
• Butyloxyanisole (antioxidant, preservative, acidity regulator);
• Emulsion wax (emulsifier);
• Vaseline oil (lipophilic base);
• Glycerin (density regulator, solvent, has a moisturizing effect on the skin);
• Ethyl alcohol (solvent, preservative);
• Purified water.

Application technique

For the first use, eliminating wrinkles around the eyes, it is better to use Retinoic ointment 0.05%. This remedy is more gentle, but also less effective.

How to use Retinoic ointment correctly:

1. Wash with warm water. You cannot use soap or other cleaning products.
2. Dry the skin well.
3. Apply the product in a thin layer. For areas with deep wrinkles, a thicker layer can be applied.
4. It will take 20-25 minutes for the ointment to be completely absorbed.
5. After the ointment is completely absorbed, wash with warm water and apply moisturizer to the skin.
6. Carry out the procedure strictly once a day before bedtime.

The minimum course duration is 1 month. For deep wrinkles and creases – 6-10 weeks. After the first application of the ointment, it is better to take a break for 2-3 days to monitor the skin reaction.

To enhance the effectiveness of Retinoic ointment, during use it is necessary to take complexes that contain vitamin C, E.

Homemade masks with Retinoic ointment

Due to the presence of additional components, masks with Retinoic mask have a complex effect. They help get rid of several skin imperfections at once. After removing the remnants of the mask, lubricate the skin with moisturizer.

Recipes:

1. To lighten freckles and age spots. Mix 15 ml of fresh aloe juice, 1 g of ointment, add 5-6 drops of lemon juice. Apply the mixture to problem areas, rinse with warm water after 30 minutes. The product can be stored in the refrigerator for 3-5 days.
2. To cleanse pores and fight breakouts. Mix the liquid from 1 capsule of vitamin E with an equal amount of Retinoic ointment. Apply the mixture to problem areas and leave for 20 minutes.
3. To eliminate scars and the effects of acne. Combine 1 tsp. retinoid ointment and almond oil. Treat scars and dents on the skin with the product. Wash off the mask after 20 minutes.

The method of using masks is to do sessions 2-3 times a week. The course consists of 10-15 procedures. Between courses you need to take a break of at least 2 months.

How does Retinoic ointment work?

Compared to other Retinol derivatives, retinoic acids and Isotretinoin in particular have a shallower penetration depth, which means less absorption into the body, and therefore less likelihood of serious side effects when used exclusively externally.

Vitamin A is fat-soluble, like all its derivatives. They are always in alliance with carriers - fats and fat-like substances, which means, like all fats, they penetrate the skin well.

Conclusion

Topical use of tretinoin as an anti-acne agent began almost half a century ago. Since then, it has been successfully used to treat comedonal and inflammatory acne.

Over the years, the beneficial effects of tretinoin have increased due to the understanding of its exceptional properties associated with a growing appreciation for its anti-inflammatory actions. This extensive review of tretinoin's immunomodulatory properties reveals that it has five important comedolytic properties that are considered anti-inflammatory in nature. In more recent times, tretinoin has been combined with antibacterial agents such as erythromycin, benzoyl peroxide and clindamycin to form a combination for topical acne treatment. It has proven to be very effective in treating various stages of acne.

Side effects

Burns from retinoic ointment are a common side effect and consequence of retinization. Such burns usually go away on their own after short-term withdrawal of the drug. Repeated use should be resumed with a smaller amount of a lower concentration in order to allow the skin to get used to and adapt.

Retinization is the saturation of the skin with retinoid products, in other words, their “accumulation” in the skin as a result of regular use.

This concept has two consequences:

The first is stimulation of all processes of skin cell renewal;

The second is severe skin irritation, accompanied by burning, sometimes pain and even “corrosion” of the skin, which, however, is very rare when using ointment.

The latter property underlies the action of retinoic peels.

More serious side effects are associated with the effect on the fetus.

Isotretinoin, like other retinoids, can cause deformities in the fetus, i.e. is teratogenic. Even small concentrations of the drug can cause deformities, so it’s not worth the risk. Consequently, drug therapy with this substance is carried out exclusively in women who are not pregnant or planning a pregnancy, using at least two reliable methods of contraception simultaneously, both during treatment and for the next one to two months after.

No foreign doctor will prescribe this drug to you without setting the above condition. In addition, all women who use this drug, especially in the form of tablets, are entered into a special register and their health status is monitored.

But in Russia, many dermatologists neglect this rule, not to mention monitoring women’s health when using external medications, which are called almost a panacea for everything: from wrinkles to acne.

And that is not all. When treating acne in men with Isotretinoin tablets or long-term therapy and applying Retinoic ointment to large areas of the skin (larger than the palm area), the substance can penetrate into the seminal fluid, so partners are also strongly recommended to use double contraception.

Separately, I would like to say about cosmetic preparations containing retinol and its derivatives.

There are many cosmetic preparations that contain a fairly high content of retinoids, so you should always remember:

• Cosmetics are subject to less stringent requirements than drugs;
• For cosmetics, bioavailability and the percentage of the substance entering the systemic circulation are not taken into account;
• There are also associated side effects that can have an irreversible effect, and especially no one will tell you about possible teratogenicity;
• Few cosmetic preparations have detailed instructions indicating side effects and warnings, the maximum that can be written is “consult a cosmetologist, may cause an allergic reaction, in case of contact with eyes, rinse them with plenty of water”;
• You cannot know for sure what side effects are fraught with certain cosmetic products, even your cosmetologist may not know, and manufacturers simply have not studied this aspect or are silent.

Retinoic ointment for wrinkles - reviews from dermatologists

Using drugs from the retinoid group to treat skin diseases, dermatologists found that the skin also became firmer, smoother, and the depth of wrinkles decreased. These effects were studied, and it turned out that Isotretinoin, which is part of the retinoic ointment, can significantly rejuvenate facial skin with long-term use.

Main effects of Isotretinoin –

• improves skin texture (by exfoliating dead skin cells),
• improves skin color,
• increases skin thickness and elasticity,
• reduces the secretion of sebaceous glands,
• stimulates the activity of fibroblasts in the dermal layer of the skin, which leads to stimulation of the production of collagen, elastin and hyaluronic acid. As a result, skin elasticity increases, the depth of wrinkles and fine lines on the face decreases.

Optimal concentration and timing of use of Isotretinoin to reduce wrinkles -

In the article devoted to Isotretinoin, we analyzed in detail all clinical studies that studied the optimal concentration and timing of isotretinoin use for the treatment of skin photoaging and reduction of wrinkle depth.

Conclusions from clinical studies - firstly, the optimal treatment period is at least 36 weeks. Secondly, the choice of concentration will depend on your goals: it can be either only the prevention of skin photoaging, or the need for significant changes in the skin (reducing the depth of wrinkles, increasing its thickness and elasticity).

If you only need to prevent photoaging, then it is best to use Retinoic ointment with a 0.05% concentration of Isotretinoin. Moreover, this must be done in combination with sunscreens that have a protection factor of at least SPF 30. As a result, you will get an improvement in skin color and texture, plus excellent prevention of wrinkles.

If your skin already has signs of photodamage, fine lines and wrinkles, then you need to use Retinoic ointment with a 0.1% concentration of Isotretinoin. However, during the first few weeks, doctors still recommend using 0.05% retinoic ointment first. This is due to the fact that lower concentrations at the initial stage will allow the skin to get used to the action of retinoids, and significantly reduce redness and irritation of the skin.

Keep in mind that you will see the first positive changes only after 8-12 weeks. Before this, you will definitely go through a short period of deterioration of your skin, when your skin will become flaky, dry, red, itchy and sensitive. Therefore, you should be patient. If you dare to use Retinoic ointment to treat acne and pimples, which, in our opinion, is unacceptable (the fatty components of the ointment, on the contrary, clog the pores) - prepare for a sharp worsening of acne in the first weeks.

Important: Isotretinoin-based preparations (including retinoic ointment) can indeed be used to reduce the depth of wrinkles, but it is still best to use them only in patients with sensitive or dry skin. This is due to the fact that Isotretinoin is significantly inferior in its effect on collagen synthesis to a retinoid such as Tretinoin.

But Tretinoin has significant side effects associated with severe redness and dry skin, which allows it to be prescribed only to patients with oily or normal skin (24stoma.ru). Therefore, for patients with dry and sensitive skin, it is customary to prescribe products with isotretinoin, because Although they are weaker, they have significantly fewer side effects.

Contraindications

Retinoic ointment has clear contraindications for use, including:

• Pregnancy, including planned;
• It is also contraindicated in nursing women due to the possibility of passage into breast milk;
• Hypersensitivity and skin damage, the cause of which is not clear;
• Too thin and dry facial skin;
• Vitamin A hypervitaminosis;
• Fatty liver and lipid metabolism disorders;
• Treatment with tetracycline antibiotics;
• Treatment with other retinoids.

Contraindications and side effects of the drug

Retinoic ointment is a medicine that has certain contraindications. Instructions for use contain all information about restrictions for use.

Retinoic anti-wrinkle ointment – ​​contraindications:

• individual intolerance to the components of the drug;
• pregnancy period – retinoids have a teratogenic effect;
• lactation - active components pass into breast milk;
• chronic form of pancreatitis;
• the presence of flat warts at the site of application of the ointment;
• benign and malignant neoplasms;
• violation of the integrity of the skin at the site of application;
• diseases of the blood, kidneys, liver, blood vessels, heart.

Retinoids for wrinkles cannot be combined with taking tetracycline antibiotics, hormonal drugs, or used with other drugs and products that contain vitamin A derivatives.

Retinol for wrinkles - possible side effects:

• redness, itching, excessive dryness and flaking;
• acne exacerbation - goes away within 12-15 days;
• the feeling of heat or burning after applying the ointment should be short-lived;
• attacks of nausea, headache;
• increased blood pressure;
• weakness;
• clouding of the cornea, inflammation of the conjunctiva;
• nosebleeds;
• anemia;
• increased sweating;
• muscle pain.

With prolonged use of the ointment, or in excess of dosages, dermatitis develops, the skin dries out, peels, and a rash appears.

The use of Retinoic ointment is not recommended for people with oily skin. Wax and petroleum jelly can clog pores, leading to comedones and rashes.

Side effect of the drug

Side effect of the drug

Indications for use

According to the official instructions for the use of Retinoic ointment, there are only a few indications for its use:

• Acne;
• Seborrheic dermatitis;
• Rosacea;
• Perioral dermatitis (“jams”, cracks in the corners of the lips).

However, given the positive effects of this ointment, there are several non-trivial indications for which it can be used, among them:

• Treatment of fresh scars, scars and stretch marks;
• Treatment of post-inflammatory hyperpigmentation, post-acne (after acne and wounds);
• Reduction of facial and age wrinkles that appear due to decreased skin turgor;
• Treatment of ingrown hairs after depilation.

Rules of application

Although this drug is intended for the skin regardless of location, Retinoic ointment is still more often used specifically for the facial skin.

Let's consider the methods and features of its use in each specific case, but before that it is worth learning a few general recommendations:

1. Treatment with the drug should be started with a lower concentration, especially for those who use this drug for the first time;
2. For people with very thin and sensitive skin, it is recommended to mix a small amount with Vaseline oil 1:1, gradually increasing the percentage of ointment, this way you will be able to avoid burns on the skin;
3. Treatment should be continued for at least a month (as for most retinoids) provided there are no adverse reactions;
4. When using Retinoic ointment under the eyes, do not apply it close to the eye, especially in high concentrations;
5. When applying around the eyes, retreat 1-1.5 cm from the eye, apply in a thin layer and do not rub into the skin, but rather use the advice from step 2;
6. Under no circumstances should this product be applied in the form of a mask in a thick layer over the entire face, this can lead to disastrous consequences;
7. The ointment should be applied in a thin layer locally, only to the affected area, unless the doctor prescribes otherwise.

For acne and blackheads

As a remedy for acne, retinoic ointment is applied in a thin layer to the affected areas 2 times a day. It is necessary to apply the composition to cleansed, dry skin and do not cover it with creams or other products. During the treatment period, it is better for girls to avoid decorative cosmetics in the affected area. Yes, it is not easy, however, the result is worth it.

Drugs from the retinoid group are currently the most effective treatments for all forms of acne.

Why do we choose them?

Because they have a beneficial effect on all processes occurring in the skin when acne occurs - they reduce the production of sebum and facilitate its secretion, normalize keratinization, reduce inflammation, and prevent the growth of pathogenic microbes in the pilosebaceous follicles.

Systemic (internal) retinoid therapy

(Roaccutane or high doses of retinol palmitate) is usually used for severe forms of acne. For mild forms, it is more advisable to prescribe external agents with 13-cis-retinoic acid (isotretinoin). The domestic drug Retinoic ointment is available in two concentrations - 0.1% and 0.05%, which corresponds to the content of 13-cis-retinoic acid (isotretinoin). The ointment is made on an emulsion basis (that is, it has the consistency of a light moisturizing cream), has a yellowish color, is odorless, is easily applied to the skin and absorbed. What concentration to choose, what guidelines to use in order to maximize the clinical effect? This article is devoted to these issues.

A study of the safety of retinoic ointment at all three concentrations showed that the ointment does not have an allergenic, carcinogenic, mutagenic, embryotoxic or teratogenic effect.

At the beginning of the treatment of papulopustular and comedonal acne, use Retinoic ointment 0.1% to achieve maximum effect in a shorter time. The exception is people with thin, sensitive skin (mainly blondes, red-haired people and children), who initially use an ointment of a lower concentration (0.05%), increasing it if it is well tolerated, usually after 2-3 weeks. The ointment is applied twice a day in a thin layer to the affected areas (facial skin, if necessary, back and chest). When using a high concentration ointment on the face, do not apply it to the eyelids, area around the eyes, lips, corners of the mouth and at the entrance to the nose, and also avoid getting the drug on the mucous membranes to avoid irritation.

Almost all patients on the 5-8th days of treatment experience an exacerbation reaction, manifested in an increase in the number of rashes, moderate redness and peeling of the skin, sometimes dry lips, itching. The reaction lasts from 3 days to 2 weeks, does not require additional therapy and disappears on its own, giving way to persistent improvement. In case of a pronounced exacerbation reaction, stop using the ointment for several days until it subsides. Despite the fact that the instructions for use of the ointment mention the possibility of such a reaction, it is better to warn the patient about it. Our experience shows that it is sometimes regarded by patients as intolerance to the drug and treatment is stopped. It is better to schedule your next visit to a dermatologist 10-14 days after the start of treatment; it is at this time that patients have questions and doubts, they need support and confidence that everything is going as it should. After the exacerbation reaction subsides, improvement is noted - the oiliness of the skin gradually decreases, and resolution of the rash is observed. This favorable trend continues throughout the treatment period (usually 3 months), which does not exclude the appearance of a small number of new eruptive elements. There are usually no other side effects.

The best result is achieved with comedonal acne - cleansing of comedones and reducing skin oiliness occurs within 14-21 days. Deeply located closed comedones become more superficial. With papulopustular acne, pustules (pustules) and comedones resolve first, followed by inflammatory elements; spots, cystic elements and scars are the most resistant to treatment.

To increase the concentration of the ointment in those patients for whom it was considered more appropriate to start treatment with retinoic ointment 0.05%, it is better to choose a period when 7-10 days have passed after the exacerbation reaction has subsided.

What is considered drug intolerance? How to distinguish it from an exacerbation reaction and choose the right tactics for managing the patient?

In some cases, after the first application of the ointment to the skin, the patient is bothered by a burning sensation, itching, and redness occurs. With repeated applications, these phenomena are repeated and intensified, the erythema spreads to neighboring areas, swelling of the skin occurs, redness, rashes in the form of small spots and nodules, and peeling occur. If intolerance occurs, the drug is discontinued, further treatment is carried out with drugs from other groups (not from the retinoid group!). The tactics for treating intolerance phenomena correspond to those of allergic rashes. Intolerance differs from an exacerbation reaction in the timing of its onset, the rapid development of symptoms, the presence of swelling and induration, the appearance of rashes unusual for acne that are not confined to the mouths of the pilosebaceous follicles, and the spread of rashes beyond the application of the ointment.

It should be noted that an initial burning sensation that goes away after a few seconds can be observed in people with sensitive skin if the drug is well tolerated. It is due to the presence in the ointment of a small amount of alcohol used as an antimicrobial substance.

During treatment with retinoic ointment 0.1%, another phenomenon may occur - an overdose of 13-cis-retinoic acid. Clinical manifestations of its excessive accumulation in the skin are the appearance of flaky red spots both in the places where the ointment was applied and nearby (on the neck, abdomen, shoulders, forearms, hands). Subjectively, mild itching and a feeling of increased sensitivity of the skin in places of contact with clothing, as well as when touched, are noted. In such cases, there are 2 options - stop using the ointment until these phenomena resolve, and then start using it again at a lower concentration, or immediately reduce the concentration. An overdose occurs closer to the end of the course of therapy - in the second or third month of treatment.

The use of retinoic ointment 0.05% is indicated in the following cases:

• For thin, sensitive skin prone to irritation;
• In case of excessive accumulation of retinoic acid in the skin (overdose);
• In conditions of increased solar radiation;
• As a transition period to maintenance therapy;
• For conglobate acne in the period between courses of systemic therapy.

The first two cases have already been discussed above.

Trips to southern resorts, moving to a climate zone with a hotter climate, as well as the summer period in the middle zone, are associated with increased insolation. Retinoic ointment increases skin sensitivity to sunlight. In this regard, it is better to use a lower concentration of ointment, switch to a single (at night) application of the ointment, and also use sunscreen when going out in the sun.

How to combine the use of retinoic ointment and sunscreen? Studies have shown that within 1 hour after applying retinoic ointment, its concentration in the skin reaches its maximum level. Based on this, it is recommended to apply sunscreen an hour after retinoic ointment. If too much ointment has been applied, then the excess remains on the skin, giving it an untidy, greasy appearance. In this case, before applying sunscreen, the skin can be treated with tonic, lotion, and wiped with a damp or dry cloth. The recommended level of protection is 30-40 SPF, while on the beach and for persons with sensitive thin white skin and blond or red hair - up to 60 SPF.

Upon successful completion of the main course of treatment (3 months) with retinoic ointment 0.1%, it is necessary to smoothly transition to maintenance therapy. During the transition period (1-2 months), it is recommended to use retinoic ointment 0.05% initially 2 times a day, then once at night.

After completing a course of systemic therapy with retinoids (roaccutane or retinol palmitate) for conglobate acne, the use of local retinoid therapy is also indicated - retinoic ointment 0.1% or 0.05%, depending on the condition of the skin.

Conclusion

Retinoic ointment

- a good external treatment for mild forms of acne vulgaris. The presence of two concentrations of the ointment makes it possible to make treatment more effective, provide maintenance therapy, quickly respond to skin changes by changing the concentration, and avoid overdose without losing the therapeutic effect of the drug.

prof.
IN AND. Albanova Print

Analogs

This unique drug has many effects and indications, so for each of them we have indicated separate analogues.

For clarity, analogues of Retinoic ointment are divided into groups, which can be seen in the table.

Retasol

Isotretionin preparation in the form of a 2.5% solution for external use. Contains propylene glycol and ethyl alcohol as auxiliary components. The higher concentration is due to the liquid dosage form. The main indications are also:

• Acne;
• Seborrheic dermatitis;
• Rosacea;
• Perioral dermatitis.

Due to its higher concentration, Retasol is not recommended for use on thin and damaged skin, especially under the eyes. Also, the liquid form is less effective for use against wrinkles.

The solution must be stored in the refrigerator.

We see

It is an ointment containing Retinol - Vitamin A. The remaining components are almost the same as Retinoic ointment, only the antioxidant components differ. The compositions of the products can be compared in the table .

The manufacturer is also

The official instructions for Videstim ointment include a number of indications for which this product can be used, including:

• Eczema;
• Dermatitis, including atopic dermatitis in the absence of exacerbation (i.e. in remission);
• Excessive pigmentation (cheilitis), including age-related;
• Age-related skin changes (meaning wrinkles); diseases associated with impaired skin keratinization processes, such as hyperkeratosis;
• To activate skin restoration processes after glucocorticosteroid therapy.

Advantages and disadvantages of ointment

Judging by the numerous positive reviews, Retinoic ointment has more positive qualities than disadvantages.

Advantages:

• complex action - the drug will immediately eliminate several skin imperfections;
• low price, the product can be bought at any pharmacy;
• significantly activates the synthesis of collagen and elastin;
• ease of use;
• natural composition;
• cumulative effect - the effect of using the ointment lasts 4-6 months.

The main disadvantage is that the ointment acts slowly. You can notice the result only after 4-6 weeks.

Cosmetic anti-aging cream with retinol works faster. But Retinoic ointment provides a deeper and more lasting effect. But this will take several months.

Other disadvantages - at the stage of addiction, severe peeling and increased acne are disturbing. Depending on individual characteristics, negative symptoms disappear after 2-4 weeks. Retinoic ointment is a potent medicine, so it has many restrictions on its use.

Reviews

We invite you to read the reviews of ordinary people and cosmetologists about retinoic ointment, and if you have any questions, you can always ask your question on our cosmetic forum.

I often recommend to my patients Retinoic ointment for acne and pimples in combination with Adapalene ointment, for example klenzit. This helps to speed up the maturation of acne and leave your skin looking amazing. But the desired effect is not achieved quickly; it will take time and desire.

Vasilisa, Moscow

What can I say, retinoic ointment quickly smoothes the skin. Even small scars on the skin have disappeared, which proves that retinoic ointment has an excellent renewing effect. And the healing process goes faster. However, I would like to note that the product provokes inflammation of subcutaneous acne, which can cause a lot of inconvenience. However, the skin subsequently becomes clear and smooth.

Victoria, Lytkarino

I started my journey to healthy skin, and retinoids help me with this. I used the ointment for a short time, only 5 weeks. But the results are definitely there and this proves that retinoic ointment really works. Blackheads and enlarged pores were and still are. There is still a lot of work to do, but now I know what to do.

Oksana, Moscow

Reviews from users and cosmetologists

Anti-wrinkle retinoids really help. There are many cosmetic creams from well-known brands that contain these substances. But they all have a high price. As an alternative, forums often recommend using Retinoic ointment for wrinkles and age-related skin changes.

User reviews of this method vary. Some argue that pharmaceutical cream with retinoids significantly improves the condition of the upper layer of the epidermis and activates the regeneration process at the cellular level. But you need to know how to use the product correctly.

Others say that the drug only helps with acne and does not cope with other skin imperfections.

Yulia, 40 years old

I am very pleased with the effect of using Retinoic ointment. It helps against wrinkles better than any folk remedies, and works no worse than expensive creams. I applied it every day for 3 weeks. The wrinkles on the forehead disappeared, the skin around the eyes and mouth smoothed out, became soft and elastic. Additionally, the product helps to cope with acne, which often appears before menstruation.

Christina, 53 years old

I succumbed to the general hype; on forums they constantly write about how to use Retinoic ointment for age-related changes on the skin. Everyone praises this method. I tried it too. There is no effect. It helps my granddaughter with acne, but not with wrinkles.

Olga, 33 years old

For me, Retinoic ointment has become a real salvation. I developed wrinkles on my forehead early on, and due to constant work indoors, my complexion became dull and gray. I bought retinol ointment at the pharmacy and applied it once a day for a month. The result is amazing - the forehead is smooth, the skin is clean and glowing. This inexpensive pharmaceutical product replaces expensive anti-aging creams and cosmetic procedures. There were no side effects, I plan to continue using the product after a short break.

Elena, 41 years old

I didn’t immediately become friends with Retinoic ointment. Within a month, all the internal pimples came out, and the skin was very flaky. But then everything became wonderful. Now I have smooth, very delicate skin, I like that the product effectively helps against wrinkles around the mouth and eyes. Now I use this ointment 2-3 times a week.

Inna, 36 years old

A dermatologist prescribed me Retinoic ointment to treat acne and acne. A month later, the face became matte, smooth, comedones and acne practically disappeared. A pleasant side effect is that the wrinkle between the eyebrows has smoothed out and the nasolabial folds have become less noticeable.

Before you start using Retinoic ointment, you need to study reviews from cosmetologists, real advice and recommendations from specialists.

Experts' opinion

Retinoic ointment really helps against wrinkles, reviews from doctors and cosmetologists confirm this. But the effectiveness of this rejuvenation method depends on several factors - the initial condition of the skin, individual characteristics, duration and correctness of application.

Stanislav Olegovich, cosmetologist

“I am against the use of pharmaceutical drugs for cosmetic purposes. But my patients often ask about the effectiveness of this or that product. Retinoic ointment has recently become the leader. Yes, the drug has a pronounced exfoliating effect, which leads to smoothing wrinkles and improving complexion. But a high content of the active substance is unsafe, especially with long-term use.”

Olga Ivanovna, cosmetologist-esthetician

“I cannot but admit the effectiveness of Retinoic ointment as an anti-aging agent. But this is a medicine with a large list of contraindications. When starting to use the drug without a doctor’s prescription, a person is at great risk. You may not even suspect that you have any diseases or pregnancy; use can result in serious negative consequences.”

Kira Yurievna, cosmetologist

“I use Retinoic ointment myself and recommend it to my clients. I always tell you in detail about the rules of use and possible adverse reactions. Women who decide to resort to this method of rejuvenation need to be patient; there will be no immediate results. Plus, at first there is severe peeling, you can’t sunbathe or visit a solarium. All these nuances need to be taken into account."

Doctors and cosmetologists recognize the existence of a positive side effect in the form of rejuvenation from Retinoic ointment. But they are in no hurry to use and prescribe this drug to eliminate wrinkles. The official purpose of the drug is the treatment of acne and other dermatological pathologies, which are indicated in the annotation.

Video review from a cosmetologist with more than 10 years of experience: