Activated zinc pyrithione: characteristics of the substance and use for skin diseases

Zinc preparations have been used for many centuries as effective remedies to help combat various skin problems. Zinc pyrithione is one of the modern forms of this substance, discovered in the 30s of the 20th century. Despite the relative “youth” of this component, it has been sufficiently studied. Its pharmacological properties have been studied in various studies, which made it possible to include this component in medicines. And, mainly, preparations with activated zinc pyrithione have found application in cosmetology and dermatology.

What other forms of zinc are there?

If we consider zinc in general, then in cosmetology and dermatology it is used in the form of bioactive salts. The substance is relatively safe for the body, therefore, in the production of medicines, skin care and decorative cosmetics, its use in high concentrations is allowed. Most often, for medicinal purposes, zinc salts are added to creams, shampoos, and lotions in a concentration of 0.1 to 5%.

Among zinc compounds, several of the most relevant ones, actively used in the pharmaceutical and chemical industries, should be highlighted:

• Zinc oxide – provides care for aging skin, effectively soothes it, and restores protective functions. It is often included in products to protect the skin from sun rays, as it is considered a natural UV filter.
• Zinc sulfate - the main purpose of this substance is to protect the skin from inflammation and fight pathogenic microorganisms.
• Zinc pyrithione is used to treat various skin diseases, including seborrheic and atopic dermatitis, psoriasis, and has pronounced anti-inflammatory, antibacterial and antifungal properties.

Preparations based on activated zinc pyrithione have recently become especially popular. The relevance of these products is due to the fact that they help fight serious dermatological problems, being in some cases an alternative to external hormone-containing drugs for the treatment of skin diseases.

Types of Zinc Supplements

There are a huge number of different zinc supplements available commercially for acne patients. Zinc comes in a variety of forms, and some are much more bioavailable than others.

It is very important to choose the right option because you may be wasting your money on a supplement that will not help you.

Zinc oxide is the most common type of zinc supplement. Used in most foods. It has very poor bioavailability, so don't waste your money on it.

Zinc gluconate is not the best zinc supplement, nor the most bioavailable, but it works to some extent. The study above used zinc gluconate, so it can be used to treat the skin.

Zinc sulfate - highly absorbed according to some studies. Not the best form of zinc, but not the worst.

Zinc glycinate is another good form and is absorbed better than zinc sulfate. Compared to zinc sulfate, glycinate is absorbed 16% more efficiently.

Zinc Orotate – Generally considered one of the best zinc supplements, but this has not yet been proven. This form competes with zinc picolinate.

Zinc Picolinate – Recognized as the king of all zinc supplements. Today, picolinate is the most bioavailable form. This study compared picolinate with zinc citrate and zinc gluconate and found that picolinate was best absorbed by the body.

Zinc citrate is quite well absorbed, but inferior to picolinate.

Zinc-1-methionine is another highly bioavailable form of zinc and is good for acne, so it is also considered effective.

If you see “zinc chelate” on the label, then know that it is not a specific type of zinc, but rather a specific class. Chelated zinc is a form that binds to an organic molecule to increase absorption in the body.

Zinc citrate, zinc picolinate, and zinc-1-methionine are all chelated supplements. The more precise form should be listed somewhere lower on the label.

Activated zinc pyrithione - what is it?

Products containing this substance are often used in dermatology to treat many skin diseases. This is because zinc pyrithione has the following properties:

• active against many pathogenic microorganisms (streptococci, staphylococci), inhibits the growth and reproduction of fungi of the genus Malassezia spp., which support inflammation in diseases such as atopic dermatitis, seborrhea;
• has an anti-inflammatory effect;
• has a keratoregulating and seborrheic effect, which is especially important for seborrheic dermatitis;
• Helps relieve itching.

Zinc pyrithione exerts its effect at the site of skin lesions, but practically does not penetrate into the bloodstream. Preparations based on it are used in treatment regimens for skin diseases in both adults, including the elderly, and children over one year of age.

Drugs containing (Analogs)

Level 4 ATC code matches: Zinc oxide
Zinc ointment

Zinc paste

Desitin

Sudocrem

Tsindol

Trade names of the product: Tsindol , Zinc ointment , Lassara paste , Zinc oxide , Desitin , Zinc paste . It is a component of the following products: Sudocrem , Ketocin , Valiskin , Teymurov Paste , Salicylic-Zinc ointment and others.

Contraindications and precautions

Activated zinc pyrithione preparations are usually very well tolerated by patients. The only exception in which these products are not recommended for use is increased individual sensitivity to individual components in the composition.

In the first days of treatment with a cream or aerosol based on activated zinc pyrithione, there may be a short-term burning sensation at the site of application. This is an absolutely normal phenomenon and does not require discontinuation of the drug.

Still, it is necessary to remember that preparations based on activated zinc pyrithione are medicinal, which means they must be used on the recommendation of a doctor.

Zincite

German zinc preparation with a high content of trace elements. Effervescent tablets must be dissolved in water. Reviews write that “Zinkit” has a mango aroma, but there is a slightly medicinal taste. Take 1 tablet of the drug per day immediately after meals. This supplement improves the condition of the skin, hair and nails, stimulating the production of keratin and collagen, and stabilizes the functioning of the sebaceous glands. Reviews say that Zincit helps those who have been treating acne for a long time. In just a month, the skin condition noticeably improves.

Zincite

VERWAG Pharma, Germany

The drug Zinkit is a dietary supplement to the diet, an additional source of zinc for the purpose of correcting the diet.
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Line of Skin-cap preparations with zinc-activated pyrithione

Among pharmaceutical products today it is not a problem to find drugs containing activated zinc pyrithione. As an optimal option for the treatment of atopic and seborrheic dermatitis, psoriasis and other skin problems, doctors often recommend the Skin-cap line of drugs. The product is available in several forms, which makes use as convenient as possible and allows you to include these drugs in the treatment regimen at any stage of the disease and for any form of dermatitis.

Nature's Bounty Calcium-Magnesium-Zinc

Zinc preparation made in the USA. The supplement is hypoallergenic, the package contains 100 capsule-shaped tablets. Zinc is presented here in the form of gluconate, the drug is also enriched with vitamin D3, magnesium and calcium. The product helps wounds heal faster, improves overall health, helps stop hair loss, strengthens nails and improves skin condition. Nature's Bounty Calcium-Magnesium-Zinc contains no GMOs, sweeteners, flavors or dyes.

Nature's Bounty Calcium-Magnesium-Zinc

Nature's Bounty, USA

Calcium is necessary to strengthen bone tissue and teeth.
Magnesium helps absorb calcium and prevents it from being “washed out” from bone tissue. At the same time, magnesium is necessary in the processes of nerve impulses and muscle contraction, so its intake is very important during stress and physical activity. Zinc, in turn, promotes healthy bone formation, supports immunity and healthy hair. “Calcium-magnesium-zinc” contains calcium and magnesium in an optimal physiological ratio, which helps normalize the mineral balance in the body. Vitamin D3 helps with calcium absorption and supports a healthy immune system. 5.0 1 review

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Shampoo Skin-cap

Contains activated zinc pyrithione at a concentration of 1%. The main purpose of this drug is to prevent and treat:

• psoriasis of the scalp;
• atopic dermatitis localized on the scalp;
• seborrheic dermatitis;
• oily and dry seborrhea;
• dandruff and itching;

The shampoo is used externally. Before application, the bottle with the drug must be shaken well several times. The product is used in small quantities, applied to damp hair and scalp, distributed with massaging movements, after which it is necessary to rinse the hair with clean water. Next, the shampoo is reapplied, thoroughly foamed and left on the hair for 5 minutes. This is necessary for the active substances to have their effect. After this time, the product is washed off the hair and scalp with plenty of warm water.

When treating these skin diseases, shampoo is used 2-3 times a week. The duration of treatment depends on the disease. For example, shampoo with activated zinc pyrithione is used for psoriasis for five weeks, and for seborrheic dermatitis - for two weeks. During the period of remission of the disease and to prevent relapses, shampoo is used as a prophylactic agent at least 1-2 times a week.

The best vitamins with zinc.

November 23, 2022
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Content

• Why is zinc needed in the body?
• Symptoms of zinc deficiency
• How to choose a zinc supplement
• 10 foods rich in zinc
• Top 10 best zinc preparations
• Solgar Zinc Picolinate
• Doppelhertz Active vitamin C + zinc
• Zincite
• Mirra-Zinc
• Zinc BioVea
• Evalar Zinc + vitamin C
• Country Life Calcium, Magnesium and Zinc
• Zincteral
• Nature's Bounty Calcium-Magnesium-Zinc
• Arnebia Zinc Depot

Zinc is an important trace element for the proper functioning of the body. Zinc is involved in the synthesis of enzymes and hormones, supports both the female and male reproductive systems, is an essential component of hair and nails, and strengthens the immune system.

Cream Skin-cap

This drug contains activated zinc pyrithione at a concentration of 0.2%. Intended for external use in adults and children over one year of age. Used to treat:

• psoriasis;
• atopic dermatitis, neurodermatitis;
• seborrheic dermatitis;
• dry skin.

Apply the cream to the surface of the skin after thoroughly shaking the tube. It is necessary to cover the skin with a thin layer of the drug in areas where skin lesions are localized. Use the cream twice a day. Depending on the disease, the following duration of treatment is recommended:

• for atopic dermatitis – up to 3-4 weeks;
• for psoriasis – up to 4-6 weeks.

If necessary, a second course of treatment can be carried out 1-1.5 months after consultation with a doctor.

The cream has a light texture, is easy to apply, without leaving a greasy film, ideal for localizing rashes on the face and open areas of the skin. Auxiliary components in the cream have additional caring properties - moisturize and nourish the skin.

How to choose a zinc supplement

Vitamins with zinc must be chosen like any other drug: focus on certain criteria. These include possible allergic reactions, the age of the patient (the form of release depends on this), and how obvious the signs of zinc deficiency are, it is important to study contraindications and side effects. So, in more detail:

1. Allergic reactions.
   Medicines and vitamin complexes often contain dyes, preservatives and flavors. Intolerance can be to both the main active ingredient and auxiliary components. If you are prone to allergies, be sure to consult your doctor before taking zinc.
2. Drug interactions.
   It happens that taking several specific medications is undesirable. Zinc, for example, is better not to combine with manganese, calcium, magnesium, tin, iron, copper and folic acid. Doctors recommend taking zinc only 2 hours after foods rich in these substances. Taking zinc reduces the absorption of certain antibiotics.
3. Age.
   When choosing a form of release of a zinc preparation, it is necessary to take into account the age of the patient. For children, it is better to buy zinc in the form of water-soluble effervescent tablets.
4. Level of zinc deficiency.
   If a person has a mild form of zinc deficiency (this does not affect his performance), you can simply adjust your diet and not buy a zinc supplement.

Aerosol Skin-cap

The concentration of activated zinc pyrithione in the preparation is 0.2%. The aerosol is used both for treating the scalp (a special nozzle is included), it is also suitable for treating so-called “wet” lesions, and is convenient for contact-free application, including in skin folds. Used externally to treat:

• psoriasis;
• atopic dermatitis, neurodermatitis;
• eczema
• seborrheic dermatitis.

Before use, the bottle with the drug must be shaken several times. Spray the aerosol onto the site of inflammation from a distance of about 15 cm, holding the bottle in a vertical position. If you need to treat the scalp, then for ease of application, it is recommended to use the special attachment included in the kit. In case of exacerbation of these skin diseases, the drug is sprayed 2-3 times a day, the duration of use depending on the disease is 1-1.5 months.

Country Life Calcium, Magnesium and Zinc

This American combination drug has a balanced composition: calcium, magnesium and zinc. Country Life Calcium, Magnesium and Zinc contains no colors, flavors, preservatives, gluten, yeast, salt or sugar. Zinc is here in the form of gluconate; you need to take 3 tablets of the drug per day. Magnesium improves the functioning of the nervous system, calcium is necessary for bones and teeth. In addition, the drug contains L-glutamic acid, which stimulates the endocrine system and helps the body resist stress and toxins. L-glutamic acid also helps minerals to be absorbed faster. You can buy Country Life Calcium, Magnesium and Zinc in packs of 100, 180 or 250 tablets. You need to take this zinc supplement for two to three months.

Country Life Calcium, Magnesium and Zinc

Calcium-Magnesium-Zinc + vitamin D3 is a vitamin-mineral complex produced by TM Country Life (USA), which is an additional source of three important microelements enriched with vitamin D. The composition of the drug is optimally selected for better absorption of all components and a more effective effect on the body.
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Zinc pyrithione activated in the treatment of atopic dermatitis

Atopic dermatitis is a chronic inflammatory skin disease, which is characterized by age-related rashes and is accompanied by severe itching.

As a rule, atopic dermatitis occurs in waves, that is, periods of exacerbation are replaced by relative calm and a decrease in the severity of symptoms.

An integral part of the treatment of atopic dermatitis is external therapy. For this purpose, patients with severe exacerbation can be prescribed hormonal drugs based on corticosteroids to relieve acute inflammation. The second stage, as a rule, prescribes more gentle drugs, for example, Skin-cap, as maintenance therapy. It is known that the microbiome of the skin of a patient with atopic dermatitis has its own characteristics - streptococci and fungi of the genus Malassezia, which abundantly colonize the skin, causing constant irritation and itching. That is why Skin-cap is especially indicated for atopic dermatitis - it not only helps eliminate inflammation and reduce itching, but also has an antibacterial and antifungal effect. Another difficulty in the treatment of atopic dermatitis is that the rashes differ in different periods - in younger children weeping rashes predominate, and in the older age group - peeling, dryness and thickening of the skin. The Skin-cap line offers various forms for any type of rash - the aerosol is convenient to apply contactlessly to wet areas, while the cream is suitable for dry rashes. The drugs are approved for use from 1 year of age and can be applied to any area of ​​the skin without restrictions.

Bismuth oxychloride in mineral cosmetics

The most controversial ingredient and I will devote a separate investigation to it, the third part.
I will definitely troll the smart guys and numerous experts! Yours, skeptic Sergei

Scientific literature was used in preparing the article. The translation of the name and brief conclusions are indicated in brackets: 1. Risk assessment of zinc oxide, a cosmetic ingredient used as a UV filter of sunscreens. J Toxicol Environ Health B Crit Rev. 2017;20(3) (Risk assessment of the use of zinc oxide in sunscreens. Conclusion: Safe) 2. The safety of nanoparticles in sunscreens: An update for general practice. Aust Fam Physician. 2016 Jun;45(6) (Safety of using nanoparticles in sunscreens) 3. Long-term exposure to commercially available sunscreens containing nanoparticles of TiO2 and ZnO revealed no biological impact in a hairless mouse model. Part Fiber Toxicol. 2016 Aug 17. (Long-term exposure to commercially available sunscreens containing TiO2 and ZnO nanoparticles did not reveal any biological effects in a model without hair. Conclusion: There is no reason to avoid the use of sunscreens containing titanium dioxide and zinc oxide nanoparticles) 4. Safety evaluation of sunscreen formulations containing titanium dioxide and zinc oxide nanoparticles in UVB sunburned skin: an in vitro and in vivo study. Toxicol Sci. 2011 Sep;. (Evaluation of the safety of sunscreen formulations containing titanium dioxide and zinc oxide nanoparticles during ultraviolet irradiation of the skin: study) 5. Effect of flexing and massage on in vivo human skin penetration and toxicity of zinc oxide nanoparticles. Nanomedicine (Lond). 2016 May;11 Effect of flexion and massage on the penetration of zinc oxide nanoparticles into human skin

Previous chapters: 1. The bitter truth about mineral cosmetics. Part 1 2. Titanium dioxide in mineral cosmetics. Part 2: Conducting experiments

Zinc pyrithione in the treatment of seborrheic dermatitis

Seborrheic dermatitis, or seborrhea, is a chronic disease that is inflammatory in nature and is accompanied by the formation of inflammation and peeling in areas with a high accumulation of sebaceous glands. With seborrheic dermatitis, most often the foci of inflammation are located in the scalp, behind the ears, in the chest area, as well as in large skin folds (in the groin area, under the mammary glands). Inflammation in seborrheic dermatitis is maintained by the activation of Malassezia fungi on the skin.

Treatment of seborrheic dermatitis is prescribed in a comprehensive manner; for mild and moderate cases of the disease, medications with activated zinc pyrithione are necessarily prescribed. They help reduce inflammation and are active against fungi of the genus Malassezia, which makes it possible to achieve stable remission. Since foci of inflammation are usually localized in the scalp area, it is recommended to use a special medicated shampoo Skin-cap. It not only helps reduce itching and inflammation, but also eliminates the problem of dandruff, without affecting the color and structure of the hair.

Why does the body need zinc?

Zinc is an important trace element in the human body. It is a mineral that is essential for energy metabolism, protein synthesis, strengthening the immune system, tissue regeneration and wound healing, muscle recovery, improving digestion and regulating hormone production. Since zinc does not accumulate in the body for a long time, daily consumption of foods containing this trace element is necessary for overall health. Moreover, zinc deficiency greatly affects the skin - and more on this below.

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Zinc pyrithione in the treatment of psoriasis

Psoriasis occurs in approximately 2-3% of people inhabiting the planet. This disease is inflammatory in nature, accompanied by the formation of psoriatic plaques, peeling and itching. Preparations with activated zinc pyrithione help eliminate all these manifestations and alleviate the course of psoriasis. Since psoriasis is an incurable disease, patients should always have a safe drug in their arsenal that can be used “as needed” to control the disease without the risk of serious side effects. One of these drugs is Skin-cap. It can be used as maintenance therapy for psoriasis on its own or after a course of hormonal therapy.

Arnebia Zinc Depot

Zinc preparation in tablet form. The supplement is indicated for those who want to supplement their diet with important microelements to strengthen the immune system during viral infections. In addition to zinc, Arnebia Zinc Depot contains vitamin C, which protects cells from stress and strengthens blood vessels. The zinc in this product is an excellent antioxidant that maintains optimal levels of cholesterol and vitamin A, and also helps heal wounds, strengthens hair and nails, and improves skin condition.

Arnebia Zinc Depot

Nutrilo Gmbh, Germany

Arnebia Zinc Depot can be recommended as a biologically active food supplement - an additional source of zinc and vitamin C.
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Zinc-containing animal products

The element necessary for the body is found in many of the most common food products: grains, different types of nuts, fish and meat foods, wheat bran. Moreover, it is found in almost all yeast, as well as in poultry meat, inside onions and garlic, and in vegetables (only fresh).

Nuts and plants are, of course, rich in this element. But nutritionists believe that the most zinc-containing foods are meat and fish. Plant foods also contain zinc, but animal products are more abundant.

Among animal products, mention should be made of the egg yolk, which contains as much as four milligrams of this element per hundred grams of the substance, as well as dairy products. It can be milk, kefir, sour cream, and yogurt. Zinc is also found in sausages, but only in natural ones.

Zinc in meat products

From meat, this is, first of all, chicken heart, fried lamb liver and kidneys. Beef, pork, and lamb are classic examples of high-calorie foods that contain elements necessary for the body, including zinc.

Zinc in seafood

The most zinc-containing fish products are seafood products. And anchovies contain three and a half milligrams of zinc per hundred grams. Sardines, tuna, oysters are both tasty and healthy products containing useful microelements. Tuna in oil is a real delicacy, and salmon can be preserved and eaten for dessert for a long time.

Iron

Iron deficiency anemia is present to varying degrees in 40–60% of women of childbearing age worldwide [2, 26]. And this despite the fact that iron is one of the most important microelements necessary for the normal functioning of the body’s biological systems. It is required for the function of respiration, hematopoiesis, and participates in immunobiological and redox reactions.

Causes of iron deficiency:

• insufficient intake of iron due to poor diet (for example, a vegetarian diet);
• decreased absorption of iron in the intestine (Fig. 3);
• dysregulation of vitamin C metabolism;
• excessive intake of phosphates, oxalates, calcium, zinc, vitamin E into the body;
• intake of iron-binding substances into the body;
• increased consumption of iron (during periods of intensive growth and pregnancy);
• iron loss associated with injuries, blood loss during operations, heavy menstruation, peptic ulcers, donation, and sports;
• dysfunction of the thyroid gland;
• various systemic and tumor diseases [21].

Given the high prevalence of iron deficiency in the population, it is difficult to talk about normal collagen synthesis in such conditions.

Does zinc oxide have any contraindications?

Zinc oxide is an inert mineral and is harmless to the skin and general health. Its use in cosmetic products is considered safe and does not carry the risk of irritation; on the contrary, it dries out all types of inflammation, acne and pimples and has a beneficial effect on the skin.

Its diverse range of actions solves the problem of rashes on oily and combination skin. Suitable for sensitive facial skin, it has an intense soothing effect.

You can often hear that zinc oxide is harmful. Whoever claims this is wrong. Zinc oxide used in cosmetics is considered completely safe for humans. It is in their composition, it is a pure compound with a very low content of heavy metals, meeting the requirements of the European Union and the USA.

Zinc oxide is contraindicated only in rare cases of individual skin sensitivity.

Zinc 25 mg in the form of effervescent tablets from Evalar

Did you know that the effervescent form, when dissolved in water, allows the release of carbon dioxide? It is this that enhances the absorption activity of the gastrointestinal tract, increasing the bioavailability of the mineral. Taking these features into account, the Evalar company has created a new product - Zinc in effervescent form, for maximum bioavailability. One tablet contains 25 mg of zinc, that is, 167% of the daily value. Dietary supplements with such a concentration of the active substance are especially useful to take during the cold season, as well as at the first signs of malaise.

Zinc Picolinate from Now Foods

It is an absorbable form of zinc enclosed in a picolinic acid chelate complex. This drug contains 50 mg, that is, its daily dose for an adult is 333%, which is required only for severe deficiencies. Be careful and be sure to consult your doctor before taking it.

Zinc Picolinate, 50 mg, 60 Vegetarian Capsules, NOW

999 ₽

Dietary supplement NOT A MEDICINE

Daily requirement of zinc

This norm was introduced back in the 70s.

In general, the dosage is prescribed by the doctor. Zinc is needed in increased portions by pregnant women, nursing mothers, and athletes. And vegetarians should at least take vitamins that contain it.