Overage – four variations on the theme of hyaluronic acid 

With the appearance of the first wrinkles, women immediately think about a method for removing them, thanks to this the beauty industry is thriving. Every year new procedures and drugs appear to combat this problem.

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The most popular are injection forms of release, of which there are over a hundred items on the pharmaceutical market. Many items have a common composition, but differ significantly in cost, and it is sometimes very difficult for patients to choose among such a variety.

In this article we will talk about the Overage line of anti-aging drugs. The main component of all cosmetics is hyaluronic acid. There are four main positions: three types of Overage fillers, which have different densities and biorevitalizant skinbooster.

All cosmetic gels from the Overage series are administered subcutaneously by injection. They are intended to correct age-related changes in the skin, most often used in cosmetology, but cases of use in ophthalmology have been recorded. They are a more affordable alternative to expensive drugs based on hyaluronic acid.

The gels have the highest level of purification and a wide range of indications, which allows you to select a specific product for each patient, taking into account his state of health.

One of the features of the drugs is considered to be the special structure of HA molecules, with the help of which it is possible to achieve the fastest and at the same time long-lasting effect from the procedure.

Characteristic features of fillers

The Overage line of gels consists of four positions, namely:

• Deep;
• Deeper;
• Derma;
• Meso.

The active substance of each product is hyaluronic acid of non-animal origin with a high level of purification, which in turn protects patients from unwanted negative effects and allergic reactions. The manufacturer of these products is a company from Italy, Overage Mesotech.

Read more about the properties of hyaluronic acid, its action and preparations in our article.

The main features of the cosmetic product include the following:

1. In the instructions for use, the manufacturer states that the gel is not capable of creating the “Tyndall effect,” that is, when injected under the skin, it is absolutely invisible, even in people with very thin epidermis.
2. 23 mg/g is the concentration of hyaluronic acid, which is found in all four positions. The differences between the drugs lie in the molecular weight of the active component. The larger the mass of acid, the longer the effect will last, and the faster the result will be visible. Hyaluronic acid with the highest molecular weight is contained in Deeper gel, which allows you to observe the effect of the procedure for 1.5 years.
3. To form a strong bond in fillers, a substance from the ester group, namely BDDE, is used.
4. Hyaluronic acid can be found in fillers, both in stabilized and unstabilized form. Due to this, drugs are used not only to correct skin defects, but also to moisturize it.

Overage gels are packaged in 1 ml syringes, which greatly simplifies the work of cosmetologists, since there are products based on hyaluronic acid, which must be diluted with 0.9% sodium chloride solution before direct administration. In addition, the package is equipped with two sterile needles, instructions on how to administer the gel and stickers.

Fillers OVERAGE (Italy)

DERMA – DEEP – DEEPER

Monophasic – Mono-sealed – Polycomponent

Monophasic gel of reticulated hyaluronic acid of non-animal origin with a high degree of purification and the same concentration of HA - 23 mg/ml.

All three fillers - mono-densified - were stabilized only once. The binding agent is BDDE, and unreacted cross-linkers are carefully removed; the drugs have a very high degree of purification, and as a result, there is no risk of toxic effects and delayed complications that can occur when the reticulating agent accumulates in the body.

Multicomponent

The stabilized hyaluronic acid gel in Overage fillers is crushed using a modern homogenization method, which makes it possible to obtain a specified range of particles in the gel substance, strictly defined for each Overage filler.

The structure of the gel, which contains both smaller and larger particles, creates conditions for ideal biointegration of the filler in tissues, good filling and redistribution of the drug.

The line includes three drugs - DERMA , DEEP and DEEPER . Accordingly, DERMA contains the smallest particles, DEEP slightly larger and DEEPER the largest. The table shows the characteristics of the hyaluronic acid gel substance for each filler separately.

What does such a scatter of particles give us?

We know that the larger the hyaluronic acid particle, the smaller the total surface area for reacting with hyaluronidase; accordingly, the biodegradation process will be delayed and slow. And vice versa, the smaller the particles, the greater the total area for interaction with enzymes; accordingly, the filler will remain in the tissues for a slightly shorter period of time. Accordingly, as can be seen from the table, DEEPER has the largest particles - the biodegradation process will take longer than the other two fillers; the period of residence in the tissues of Overage DEEPER is 18 months.

This cutting of the gel into fillers gives a very plastic structure with high biointegration properties; the fillers fit very well into the tissues and do not require careful kneading and styling. This structure is ideal for working with cannulas.

OVERAGE DERMA , the first product in the Overage line. The gel structure has a range of particles with the smallest sizes and 3% stabilization. The drug is very plastic and delicate. Overage DERMA is a drug for working mainly with the dermal layer, as can be seen from the name of the drug. Filler for the correction of shallow wrinkles and folds of any localization. This is work in the periorbital area, correction of “crow’s feet”, even with very thin skin - the structure of the filler ensures excellent filling and integration of the gel into the tissue, without providing any overcorrection, nor translucency and visualization of the drug even on the thinnest skin. Work with the perioral area – purse-string wrinkles, shallow nasolabial folds and “sorrow” wrinkles. The neck and décolleté area is a very delicate area for correction due to the very thin skin in these anatomical areas.

The problem of translucency of the drug when correcting longitudinal wrinkles at a certain angle of incidence of light, the so-called “Tyndall effect,” is also important. When working with Overage fillers, in particular with DERMA, this effect is excluded. Overage DERMA filler can be safely used when working with the skin of the neck and décolleté and not be afraid, again, due to the very high biointegration of the drug, to work with delicate areas, we get a good and natural correction.

Overage DERMA is also the drug of choice for correcting and restoring lost shape and volume of aging lips. The drug creates a well-defined contour with a very natural elaboration of the lip parenchyma. Prolongation of the presence of the drug in tissues is 8-10 months.

Overage DEEP and DEEPER fillers are volumizers, designed to work with both needle and cannula techniques. The preparations are plastic, adhere well to tissues and do not require active manual styling.

OVERAGE DEEP is a volumizing filler for lip augmentation, soft modeling of volumes and correction of wrinkles and folds of medium and deep depth. The structure of the drug is a gel of 7% stabilized mid-range hyaluronic acid. Overage DEEP is a drug for working with both a needle and a cannula; in both cases, the drug behaves very well in tissues and is easy for a cosmetologist to work with.

The areas of application of the drug are wide. Lip augmentation with this filler is good for young lips, for adding plumpness to the lips, and, if desired, changing the shape and volume of the lips. The filler distributes well and lays down softly. Even during the procedure itself, the accumulation of the drug is often not felt under the fingers. The filler does not require active kneading. The patient has no sensation of a foreign body in the tissues.

Correction of medium and deep wrinkles and folds with Overage DEEP filler is carried out both with a needle and a cannula, if necessary, to create a hypodermal “platform” under the dermal crease. Overage DEEP is suitable for the correction of pronounced nasolabial folds, grief wrinkles, and for the correction of nasolacrimal and nasobuccal grooves.

Volumization with Overage DEEP filler is soft and natural. This is the replacement of minus tissue, for example, in the temporal region, recreating, soft and natural, the volumes of the zygomatic, cheek, and chin areas. Overage DEEP is working with the “shadows” of the face, areas of minus tissue and areas of missing volume. This is a prolonged correction, lasting 10-12 months.

OVERAGE DEEPER , filler-volumizer for working with facial architecture, for recreating and modeling volumes, from natural to pronounced, for supporting and lifting reinforcement. The structure of the filler contains particles with a diameter of 0.5-1.25 mm, 9% stabilization, which gives excellent modeling properties to the filler, as well as prolongation of correction up to 18 months.

Overage DEEPER is very good for working with cannulas. The flexible distribution of the drug, good placement under the fingers and cost-effectiveness make the cosmetologist’s work easier and give good aesthetic results. Areas of administration: lips, dermis, hypodermis, periosteum.

Using Overage DEEPER filler, you can model the volume of the zygomatic and cheek areas, model the oval of the face, the shape and volume of the chin area, correct the shape of the nose, and achieve prolonged pronounced lateral lifting of the eyebrows.

Overage DEEPER is also intended for the correction of deep wrinkles and folds, which implies both its hypodermal position and the dermal position.

Overage DEEPER is injected into the deep dermis if we need dermal work. At the level of the deep dermis, working in the technique of dermal reinforcement with a needle, with the help of this filler you can achieve a good lifting effect, especially for the middle third, when you need to stop the phenomena of gravitational ptosis. The drug is capable, when positioned correctly, of lifting even heavy tissues, giving a lasting aesthetic result.

Overage DEEP and DEEPER are fillers with which you can and should model facial architecture, create or restore volume. When working with cannulas, these fillers fit perfectly, delicately filling the tissues, do not cause overcorrection, and due to their structure, they are immediately perfectly distributed and biointegrated.

Overage fillers are also designed to work on the body. Any of the three fillers, depending on the indications, is a good correction of atonicity and sagging tissue, and the lack of the hypodermal layer. Reinforcement with a dermal needle and cannulas at the level of the hypodermis can strengthen such delicate areas of the body as the back of the shoulder, the inner surface of the thigh, the knee area, and the abdomen. Correction of the hands gives good results when working with the Overage DERMA filler cannula. Reinforcement of the neck and décolleté area is possible with both Overage DERMA and Overage DEEP.

Overage fillers are a universal line, consisting of only three drugs, but providing ample opportunities for aesthetic correction of both the face and body.

Based on materials from the Medical Beauty Project

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Hyaluronic acidContour correctionFillers

Description of Overage cosmetics

As mentioned above, the line of drugs includes four positions. Below we will go into more detail about the main features and indications for use of each form.

Overage Derma

Overage Derma contains HA with the lowest molecular weight, which is intended for introduction into the middle layers of the skin. The main indications for use are:

• increase in lip volume;
• correction of wrinkles in the periorbital area;
• elimination of superficial wrinkles, as well as correction of nasolabial folds;
• elimination of folds in the neck, bridge of the nose, frontal area;
• correction of the skin in the area of ​​the bridge of the nose and forehead, namely the elimination of shallow creases.

The gel contains two types of hyaluronic acid, a mixture of which can reduce the number of inflammatory reactions, as well as reduce the intensity of the destructive effect of proteinases on collagen. The effect of the procedure lasts for 6-8 months.

Overage Deep

Designed for introduction into the hypodermis, middle and deep layers of the skin. Among the main purposes the following positions are distinguished:

• filling subcutaneous areas in the cheeks, cheekbones and temples;
• lip augmentation;
• elimination of medium-depth wrinkles, nasolabial and labiomental folds, nasolacrimal grooves;
• correction of atrophic scars.

Overage Deeper

Overage Deeper is the densest and heaviest gel, but this does not affect its plasticity. Injections are administered into the hypodermis and deep layers of the skin. Recommended for use:

• changing the shape of the nose without surgery;
• brow lift – laterally;
• recreating the lost volume or its modeling;
• elimination of deep wrinkles and tissue folds.

Among specialists it has a second name – filler-volumizer. The gel penetrates all layers of the epidermis, due to which it has the longest lasting effect among cosmetic products from the Overage line. Used for working with cannulas.

Overage meso

It is a biorevitalizant-skinbooster. This means that the cosmetic product not only moisturizes the skin, but is also capable of smoothing and strengthening it. The gel is intended for introduction into the middle and superficial layers of the epidermis.

Skinbooster is used for:

• moisturizing the red line of the lips;
• elimination of age-related changes on the skin of the hands;
• correction of fine wrinkles;
• eliminating dark circles under the eyes;
• elimination of small areas of scar tissue;
• for prophylactic purposes in case of skin dehydration.

Thanks to the physicochemical properties of the product, fibroblasts are activated, which helps restore the skin to a youthful and healthy appearance. It becomes more elastic and resilient.

All drugs from the Overage line have the following properties:

1. Due to the exceptional viscosity and good fluidity of the gel form, they can be introduced into tissue structures without unnecessary problems and complications. The gel is also very plastic, which provides elasticity to the skin after its administration.
2. They have the highest level of purification.
3. The toxicity of drugs is eliminated, since stabilization of the drugs occurs once. Thanks to this, the risk of complications and allergic reactions is reduced to zero.
4. Characterized by quick results and long-lasting effects. This is facilitated by the increased concentration of hyaluronic acid and all of the above benefits.
5. Cosmetics are multicomponent, since the composition contains a high concentration of stabilized hyaluronic acid and a small amount of its native form. This combination allows the gel to be evenly distributed in all layers of the epidermis.

Overage – Italian fillers for contouring and biorevitalization

The growing popularity of injection cosmetic procedures has led to the fact that there are already more than 100 different types of contouring preparations on the market. And they are all approximately the same in composition, so figuring out which one is better and why exactly is not an easy task.

Overage is a line of gels based on hyaluronic acid, which includes 3 fillers of different densities and one biorevitalizant with skin booster capabilities. How do they differ from their analogues and what problems do they solve? How long does the effect last? Why does TecRussia.ru doubt the advisability of using them? Read our detailed review:

↑ Where did these drugs come from and what did we immediately not like about them?

The developer and manufacturer is the Italian pharmaceutical laboratory Mesotech Srl, which specializes in producing a wide range of products for the needs of aesthetic medicine. In addition to fillers, her portfolio includes meso-cocktails, various masks, skin oils, compression garments, anesthetic creams, decorative cosmetics, etc.

• Overage injection gels were registered in the Roszdravnadzor register in 2015 (reg. No. RZN 2015/2885), the applicant was Laser Technologies LLC - this company operates under the OverCosmo brand, sells this line of drugs and conducts seminars on them for cosmetologists.
• In addition, Lantana LLC (Lantana Group) operates in the Russian Federation, which also actively sells Overage fillers, trains doctors and attracts representatives to work in the regions.
• The most interesting thing here is that each of these companies calls itself the “sole official distributor” and emphasizes that no one else has such status. They do not directly accuse each other of selling counterfeits and fakes, but they are very actively trying to create the impression that it is impossible to purchase the original drug anywhere except from them.

Of course, such methods of competition not only do not benefit them, but also mislead cosmetologists and patients. Where exactly are the drugs purchased? Do Lantana or Overcosmo have an exclusive agreement with Mesotech Srl or do they both work through intermediaries? Can they guarantee the quality of the products? Both (!) companies refused to discuss these issues with TecRussia.ru. Now let's look at the product itself:

↑ Composition, features and indications for use of Overage fillers

The line includes 4 items - Meso, Derma, Deep and Deeper. The main active ingredient of each of them is hyaluronic acid of non-animal origin, of a high degree of purification, which guarantees good tolerance of injections by the body without the risk of developing allergies and other adverse reactions.

• To bind the molecules, as in most other fillers, BDDE ester is used.
• Fillers contain both stabilized and native (unstabilized) hyaluronic acid, therefore, in addition to volumetric correction, they also provide a pronounced effect of tissue hydration.
• The concentration of HA in all these drugs is the same - 23 mg/ml, and the difference in effects is achieved due to the use of molecules of different masses in each of the products - the higher it is, the more extensive the result can be and the longer the filler lasts in the tissues. They promise that the densest gel - Overage Deeper - will work for up to 18 months.
• A separate advantage is the absence of the “Tyndall effect” - that is, theoretically, these fillers should not be translucent and visible from the outside, even in patients with very thin skin.

Overage fillers are available in 1 ml syringes. The preparations are completely ready for use and do not require dilution with saline or other preliminary manipulations. Each package must contain two sterile needles for administering the gel, instructions for use and stickers.

↑ How the procedure is performed

Contour plastic surgery or biorevitalization with Overage preparations should be performed only by a qualified specialist in a cosmetology or treatment room, in compliance with all sanitary rules:

• The first step is to prepare the skin for injections: remove makeup and dust particles from the face, apply anesthetic cream, antiseptic and the necessary markings.
• When the anesthetic takes effect, you can proceed to injections. The filler or biorevitalizant is injected into pre-designated points, after which it is gently distributed into the tissues with the fingers.
• Upon completion, the skin puncture sites are again treated with an antiseptic, and the patient is given recommendations for facial care.

The entire procedure from start to finish takes about 1 hour. Immediately after this you can go home. You should not plan a session “during lunch break” or on the eve of important public events - traces of injections will remain on the face for at least 2-3 days. The final result lasts up to 12-18 months for fillers and about 3-6 months for biorevitalizant, after which the procedure will need to be repeated.

• Beauty injections: what can injection cosmetology do?
• Fillers in nasolabial folds: detailed educational program

↑ Contraindications, complications, possible side effects

Overage line products are pure hyaluronic acid without additional impurities. Therefore, the factors that exclude the possibility of carrying out the procedure are the same as for any other fillers of a similar composition:

• the presence of foci of inflammation on the skin in the injection area;
• tendency to form hypertrophic and keloid scars;
• blood clotting disorder;
• severe decompensated diseases: diabetes mellitus, heart and vascular diseases;
• autoimmune diseases;
• allergy to any of the components of the gel.

Similarly with complications and side effects - these gels cannot cause any specific troubles, but all the risks typical for procedures using HA remain:

• Large and small bruises usually resolve on their own without treatment, but can seriously damage the face in the first 1-2 weeks after the injections.
• The appearance of swelling - it will not be possible to completely avoid it either, but it can be reduced by periodically applying a cold compress to the chipped area.
• Insufficient or excessive correction, as well as the appearance of asymmetry due to uneven distribution of the gel - it all depends on the skill of the cosmetologist. If you don’t like the result of the procedure, you can either inject a little of the drug or remove the excess using hyaluronidase.
• Papules after biorevitalization are numerous bumps on the face caused by a special injection technique (multiple injections). They pass quickly and usually do not cause serious inconvenience.
• For more details, see the article “Complications after contouring.”

↑ How much do Overage fillers cost? Current prices

Very few cosmetologists work with these drugs. They appeared on the market quite recently and do not have significant advantages over their analogues. However, patients will have to pay quite a significant amount for the procedure.

Thus, these gels cost approximately the same as more popular, proven brands from the middle price segment - such as Princess, Bellcontour, Repleri, etc. You can save only by tracking various promotions in salons and clinics; in this case, you can find discounts of up to 20-30%.

↑ Conclusions TecRussia.ru

• Overage preparations are practically no different from other gels based on hyaluronic acid. The declared advantages are essentially not such, since approximately the same properties are found in any other modern fillers. There are currently no negative or confidently positive reviews from cosmetologists about them.
• The obvious disadvantage is the complete opacity of the selling companies and their reluctance to restore order in their relationships with each other and with the manufacturer. Given the availability of a huge number of drugs on the market of the same and better quality at a similar price, there is no point in choosing this one, at least until there is at least some certainty in its status.
• Based on the above, we do not recommend patients to use fillers and biorevitalizant from the Overage line. The exception is if it is recommended by a cosmetologist whom you completely trust. Each doctor works with those gels with which he gets optimal results, and the ability to properly prescribe drugs of a certain brand is, of course, more important than the behind-the-scenes intrigues of “official distributors”.

Methodology for rejuvenation procedures using Overage gels

Biorevitalization and contouring with Overage preparations are performed by a licensed specialist under conditions of absolute sterility in order to avoid infection of the injection site.

The procedure is carried out in several stages:

1. Cleansing the skin of cosmetics.
2. Treatment of the skin with an antiseptic, followed by application of a local anesthetic cream.
3. Designation of intended injection sites.
4. After the anesthetic has taken effect, you can begin the direct administration of the cosmetic gel.
5. The gel is carefully distributed with your fingers at the injection site.
6. After the procedure is completed, the skin is re-treated with an antiseptic solution.
7. The doctor informs the patient about further care and behavior.

The duration of the procedure ranges from 40 to 60 minutes. The final result of the procedure lasts for 1-1.5 years for Overage fillers, and up to six months for Overage meso.

Side effects

There are no specific adverse reactions after using Overage hyaluronic acid. The most common of them include:

1. Formation of small bruises and bruises at the injection site.
2. If multiple injections of the drug were performed (during the procedure of biorevitalization or mesotherapy), then papules may appear, which will go away on their own over time.
3. If a specialist does not have special skills, he may incorrectly distribute the gel under the skin, and as a result, areas of asymmetry will arise. If an excessive amount of gel has been introduced, it is removed using hyaluronidase, and if there is not enough gel, then the required amount is added.
4. Tissue swelling is the most common side effect, as it is almost impossible to avoid. To make the swelling go away faster, you need to apply a cold compress to the injection area.